Head lice are becoming resistant to commonly used topical insecticides, and researchers have begun to look for alternatives.
The oral drug ivermectin, cured more head lice infestations than malathion in a randomised trial . The authors randomised 376 families with persistent infestations of head lice.
Affected family members had a mean age of 10 and had two treatment sessions eight days apart.
The active component was either oral or a lotion containing 0.5% malathion, which was applied to dry hair and left in for 10-12 hours. The trial was paid for by companies with a commercial interest in ivermectin.
The ivermectin seemed to work significantly better after 15 days and caused no more side effects than the malathion lotion.
One 7 year old girl had a convulsion six days after taking ivermectin.
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